Background: Vulvovaginal candidiasis (VVC) is a very common debility in gynecology clinics. Despite access to several antifungal agents, VVC is still a challenge; therefore, presenting a novel antifungal agent, especially with a traditional origin, is of interest and demand.

Objectives: The current study aimed at comparing the efficacy of Anethum graveolens L.(dill) vaginal cream with that of 1% Clotrimazole vaginal cream to treat VVC.

Methods: A prospective, single-center, randomized, double-blind clinical trial was performed. In the current study, married females aged 18-65 years, with probable vulvovaginal candidiasis were enrolled for primary evaluation. After VVC confirmation by the sniff test, the patients were allocated into three groups with regard to blocked randomization, and inclusion and exclusion criteria. The first group (n= 59) was treated with 1% Clotrimazole vaginal cream; the second (n= 60) with a combination of dill seed essential oil and dried aqueous extract vaginal cream (TEE); and the last (n= 56) with dill seed essential oil vaginal cream (EO) for seven nights.